SCHEMBL31334426

SCHEMBL31334426

O=C(CBr)N[C@H]1CC[C@H](Nc2ncc(Cl)c(-c3cccc(-c4ccc(F)cc4)c3)n2)CC1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 19/20 0.49
GRIN2B Q13224 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334224 0.85 MAPK1 (0.49) MAPK1
SCHEMBL31333534 0.84 MAPK1 (0.45) MAPK1
SCHEMBL31334026 0.83 MAPK1 (0.48) MAPK1
SCHEMBL31334056 0.82 CCNT1 (0.57) MAPK1
SCHEMBL31334180 0.82 CCNT1 (0.47) MAPK1
SCHEMBL31333940 0.81 MAPK1 (0.48) MAPK1GRIN2B
SCHEMBL31333711 0.80 MAPK1 (0.48) MAPK1
SCHEMBL31334996 0.79 ADORA1 (0.51) MAPK1
SCHEMBL31334822 0.79 ADORA1 (0.51) MAPK1
SCHEMBL31334419 0.77 ADORA1 (0.53) MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed