SCHEMBL31334475

SCHEMBL31334475

O=c1ccc(C(F)(F)F)cn1-c1cccc(Br)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CBL P22681 1/20 0.45
CBLB Q13191 1/20 0.45
MGLL Q99685 1/20 0.42
HTT P42858 1/20 0.41
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
ALDH1A1 P00352 3/20 0.39
KDM4E B2RXH2 2/20 0.39
CYP1A2 P05177 1/20 0.39
HPGD P15428 1/20 0.39
BLM P54132 1/20 0.39
HSD17B10 Q99714 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
POLB P06746 1/20 0.38
RECQL P46063 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
PTGS2 P35354 2/20 0.38
PTGS1 P23219 1/20 0.38
ALKBH5 Q6P6C2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4860704 0.86 HTT (0.55) CBLCBLBHTTMEN1KMT2A
SCHEMBL16479475 0.83 CBL (0.46) CBLCBLBMGLLHTTMEN1
SCHEMBL29348797 0.82 KDM4E (0.42) CBLCBLBMGLLMEN1KMT2A
SCHEMBL143208 0.82 ALDH1A1 (0.56) CBLCBLBALDH1A1KDM4ECYP1A2
SCHEMBL16474660 0.82 HTT (0.51) HTTMEN1KMT2AALDH1A1CYP1A2
SCHEMBL16479477 0.79 TP53 (0.50) CBLCBLBMGLLHTTMEN1
SCHEMBL12333052 0.78 GSK3A (0.42) CBLCBLBALDH1A1KDM4ECYP1A2
SCHEMBL3300493 0.76 ALDH1A1 (0.64) MGLLMEN1KMT2AALDH1A1KDM4E
SCHEMBL14269326 0.75 PTGS2 (0.36) CBLCBLBMGLLHTTMEN1
SCHEMBL31334295 0.75 CBL (0.43) CBLCBLBHTTALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed