SCHEMBL31334811

SCHEMBL31334811

O=C(N1CCC(Nc2ncc(Cl)c(-c3cccc(-c4ccc(F)cc4)c3)n2)CC1)C1(O)CCNCC1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 12/20 0.46
MAPK8 P45983 8/20 0.42
MAPK9 P45984 8/20 0.42
JUN P05412 7/20 0.42
CDK2 P24941 7/20 0.42
MAPK10 P53779 5/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333401 0.88 MAPK1 (0.50) MAPK1MAPK8MAPK9JUNCDK2
SCHEMBL31334839 0.86 CCNT1 (0.48) MAPK1MAPK8MAPK9JUNCDK2
SCHEMBL31333711 0.82 MAPK1 (0.48) MAPK1MAPK8MAPK9CDK2
SCHEMBL31334224 0.81 MAPK1 (0.49) MAPK1MAPK8MAPK9JUNCDK2
SCHEMBL31334032 0.81 MAPK1 (0.46) MAPK1MAPK8MAPK9JUNCDK2
SCHEMBL31334130 0.80 MAPK1 (0.47) MAPK1MAPK8MAPK9JUNCDK2
SCHEMBL31334722 0.80 MAPK1 (0.53) MAPK1MAPK8MAPK9JUNCDK2
SCHEMBL31333534 0.80 MAPK1 (0.45) MAPK1CDK2
SCHEMBL31334054 0.79 CCNT1 (0.52) MAPK1MAPK8MAPK9JUNCDK2
SCHEMBL31335001 0.78 MAPK8 (0.51) MAPK1MAPK8MAPK9JUNCDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed