SCHEMBL31334839

SCHEMBL31334839

CC(C)(C)OC(=O)N1CCC(O)(C(=O)N2CCC(Nc3ncc(Cl)c(-c4cccc(-c5ccc(F)cc5)c4)n3)CC2)CC1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 1/20 0.48
MAPK1 P28482 8/20 0.45
MAPK8 P45983 4/20 0.44
MAPK9 P45984 4/20 0.44
MAPK10 P53779 2/20 0.44
IDH1 O75874 1/20 0.43
IDH2 P48735 1/20 0.43
SYK P43405 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
DYRK2 Q92630 1/20 0.41
DNMT3A Q9Y6K1 1/20 0.41
JUN P05412 3/20 0.41
CDK2 P24941 3/20 0.41
CDK9 P50750 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334054 0.93 CCNT1 (0.52) CCNT1MAPK1MAPK8MAPK9MAPK10
SCHEMBL31335014 0.89 CCNT1 (0.49) CCNT1MAPK1MAPK8MAPK9MAPK10
SCHEMBL31333217 0.86 MAPK8 (0.54) CCNT1MAPK1MAPK8MAPK9MAPK10
SCHEMBL31334296 0.86 MAPK1 (0.46) CCNT1MAPK1MAPK8MAPK9MAPK10
SCHEMBL31334811 0.86 MAPK1 (0.46) MAPK1MAPK8MAPK9MAPK10JUN
SCHEMBL31334823 0.84 DYRK2 (0.52) CCNT1MAPK1IDH1IDH2SYK
SCHEMBL31333916 0.83 MAPK1 (0.53) CCNT1MAPK1MAPK8MAPK9MAPK10
SCHEMBL31333535 0.83 MAPK1 (0.46) CCNT1MAPK1MAPK8MAPK9MAPK10
SCHEMBL31334616 0.82 MAPK8 (0.51) CCNT1MAPK1MAPK8MAPK9MAPK10
SCHEMBL31333428 0.82 MAPK8 (0.47) CCNT1MAPK1MAPK8MAPK9MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed