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Sugi Predict / Compounds / SCHEMBL31334032

SCHEMBL31334032

SCHEMBL31334032

O=C(O)N1CCC(C(=O)N2CCC(Nc3ncc(Cl)c(-c4cccc(-c5ccc(F)cc5)c4)n3)CC2)CC1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 17/20 0.46
▸ JUN P05412 3/20 0.42
▸ CDK2 P24941 3/20 0.42
▸ MAPK8 P45983 3/20 0.42
▸ MAPK9 P45984 3/20 0.42
▸ MAPK10 P53779 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333401 0.91 MAPK1 (0.50) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31333959 0.91 MAPK1 (0.48) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31335001 0.89 MAPK8 (0.51) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31335014 0.88 CCNT1 (0.49) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31334759 0.87 MAPK1 (0.44) MAPK1
SCHEMBL31335038 0.86 CDK2 (0.54) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31334860 0.86 MAPK1 (0.56) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31334904 0.86 PKM (0.47) MAPK1
SCHEMBL31334722 0.85 MAPK1 (0.53) MAPK1JUNCDK2MAPK8MAPK9
SCHEMBL31334224 0.85 MAPK1 (0.49) MAPK1JUNCDK2MAPK8MAPK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 — — EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 — — WO disclosed