Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL27697714 | 0.98 | CYP2D6 (0.52) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL11308536 | 0.98 | ALDH1A1 (0.52) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL29368513 | 0.90 | NUDT1 (0.50) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL68186 | 0.90 | NUDT1 (0.50) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL29623103 | 0.88 | NUDT1 (0.49) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL13609954 | 0.88 | NUDT1 (0.49) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL2913462 | 0.85 | HSP90AA1 (0.43) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL2340495 | 0.84 | ESR1 (0.49) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL17354422 | 0.84 | NUDT1 (0.46) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL13609943 | 0.84 | NUDT1 (0.46) | CYP2D6CYP1A2CYP2C19ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137193-B1 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI SA (FR) | 2017-08-09 | — | — | EP | disclosed |
| US-8642603-B2 | Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof | SANOFI (FR) | 2014-02-04 | — | — | US | disclosed |
| US-20100075994-A1 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2010-03-25 | — | — | US | disclosed |
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |
| US-6096293-A | APPLYING ORAL COMPOSITION CONTAINING 2,4-DI-TERT-BUTYL PHENOL TO TEETH | COLGATE-PALMOLIVE COMPANY (US) | 2000-08-01 | — | — | US | disclosed |
| US-5912274-A | WATER INSOLUBLE NONCATIONIC ANTIBACTERIAL PHENOL CONTAINING, RELATIVE TO THE HYDROXYL GROUP, AN ALKYL OR CYCLOALKYL GROUP, PREFERABLY TERT.-BUTYL (T-BUTYL), IN THE 2-POSITION, AND SUBSTITUENTS IN ONE OR BOTH OF THE 4- AND 5-POSITIONS | COLGATE-PALMOLIVE COMPANY (US) | 1999-06-15 | — | — | US | disclosed |
| US-4077962-A | WATER INSOLUBLE, GREEN-YELLOW, SYNTHETIC FIBERS | BAYER AKTIENGESELLSCHAFT (DT) | 1978-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075994-A1 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | GRM2, GRM1, GRIN2C | CYP2D6 413/4885CYP1A2 411/4885CYP2C19 377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.