Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901045 | 0.74 | TSHR (0.44) | ALDH1A1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18940861 | 0.71 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1HSD17B10KDM4EGAA | |
| SCHEMBL1705257 | 0.68 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1HSD17B10KDM4EGAA | |
| SCHEMBL396202 | 0.68 | ADRA2C (0.59) | ALDH1A1L3MBTL1HSD17B10PDK2ADRA2C | |
| SCHEMBL5154599 | 0.66 | — | — | |
| SCHEMBL20116875 | 0.66 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1KDM4EGAAPDK2 | |
| SCHEMBL20040430 | 0.66 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1HSD17B10KDM4EGAA | |
| Water SCHEMBL2442515 | 0.65 | ALDH1A1 (0.93) | ALDH1A1L3MBTL1HSD17B10KDM4EGAA | |
| SCHEMBL24768621 | 0.64 | ADORA2A (0.50) | ALDH1A1L3MBTL1HSD17B10KDM4EGAA | |
| SCHEMBL30072279 | 0.64 | ADORA2A (0.50) | ALDH1A1L3MBTL1HSD17B10KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966218-B1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER SCHERING PHARMA AG (DE) | 2010-07-14 | — | — | EP | disclosed |