SCHEMBL20040430

SCHEMBL20040430

Cc1ccc(C#N)cc1-c1ccccc1N

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
KDM4E B2RXH2 3/20 0.41
GAA P10253 3/20 0.41
PLA2G7 Q13093 1/20 0.41
NPC1 O15118 2/20 0.40
GLA P06280 1/20 0.40
MAPT P10636 1/20 0.40
RAB9A P51151 1/20 0.40
AR P10275 3/20 0.39
LMNA P02545 1/20 0.39
KDM1A O60341 1/20 0.38
CYP11B1 P15538 2/20 0.37
CYP11B2 P19099 2/20 0.37
PTGDR2 Q9Y5Y4 1/20 0.37
MAOB P27338 1/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20116875 0.86 ALDH1A1 (0.45) ALDH1A1L3MBTL1KDM4EGAAAR
SCHEMBL10694573 0.86 AR (0.42) ALDH1A1L3MBTL1KDM4EGAAAR
SCHEMBL18940861 0.85 ALDH1A1 (0.52) ALDH1A1L3MBTL1KDM4EGAANPC1
SCHEMBL18934546 0.85 AR (0.46) ALDH1A1KDM4EGAAPLA2G7NPC1
SCHEMBL20115895 0.78 KDM1A (0.44) ALDH1A1L3MBTL1KDM4EGAANPC1
SCHEMBL15856485 0.77 CA1 (0.50) ALDH1A1KDM4EGAAGLAMAOB
SCHEMBL15856481 0.77 PTGDR2 (0.49) ALDH1A1L3MBTL1KDM4EGAAAR
SCHEMBL29788076 0.77 PTGDR2 (0.49) ALDH1A1L3MBTL1KDM4EGAAAR
SCHEMBL18934331 0.76 ALDH1A1 (0.54) ALDH1A1ARCYP11B1CYP11B2PTGDR2
SCHEMBL3780745 0.76 PLA2G7 (0.67) ALDH1A1L3MBTL1KDM4EGAAPLA2G7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3053918-B1 2-carbazole substituted benzimidazoles for electronic applications IDEMITSU KOSAN CO (JP) 2018-04-11 EP disclosed