Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137891 | 0.92 | MAPK1 (0.51) | MAPK1ALDH1A1NPSR1SMN1; SMN2ALPL | |
| SCHEMBL3137243 | 0.90 | ALOX15 (0.46) | MAPK1ALDH1A1NPSR1SMN1; SMN2USP2 | |
| SCHEMBL3125839 | 0.90 | MAPK1 (0.52) | MAPK1ALDH1A1NPSR1SMN1; SMN2ALPL | |
| SCHEMBL3094493 | 0.89 | HCAR3 (0.54) | MAPK1ALDH1A1NPSR1SMN1; SMN2ALPL | |
| SCHEMBL3141633 | 0.88 | MAPK1 (0.51) | MAPK1ALDH1A1NPSR1SMN1; SMN2ALPL | |
| SCHEMBL3127630 | 0.88 | MAPK1 (0.51) | MAPK1ALDH1A1NPSR1SMN1; SMN2ALPL | |
| SCHEMBL3132297 | 0.88 | MAPK1 (0.51) | MAPK1ALDH1A1NPSR1SMN1; SMN2ALPL | |
| SCHEMBL3134666 | 0.87 | MAPK1 (0.49) | MAPK1ALDH1A1NPSR1SMN1; SMN2ALPL | |
| SCHEMBL3138202 | 0.85 | ALDH1A1 (0.48) | MAPK1ALDH1A1NPSR1SMN1; SMN2UBE2N | |
| SCHEMBL3135556 | 0.84 | ALOX15 (0.46) | MAPK1ALDH1A1NPSR1SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142528-B1 | 1-(1-BENZYLPIPERIDIN-4-YL)BENZIMIDAZ0LE -5-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS | HOFFMANN LA ROCHE (CH) | 2010-07-07 | — | — | EP | claimed |