Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31341058 | 0.90 | HPGDS (0.46) | HPGDSSREBF2GSK3BDYRK1ACDK5 | |
| SCHEMBL31341055 | 0.89 | RAB9A (0.46) | HPGDSSREBF2GSK3BDYRK1A | |
| SCHEMBL27138550 | 0.86 | HPGDS (0.52) | HPGDSSREBF2GSK3BDYRK1AALDH1A1 | |
| SCHEMBL31340994 | 0.82 | CHEK1 (0.48) | HPGDSSREBF2GSK3BDYRK1ACDK5 | |
| SCHEMBL31341012 | 0.82 | CDK5 (0.57) | HPGDSSREBF2CDK5CDK5R1CCNA2 | |
| SCHEMBL3764652 | 0.80 | SREBF2 (0.44) | HPGDSSREBF2GSK3BDYRK1ACDK5 | |
| SCHEMBL3258037 | 0.79 | CDK5 (0.55) | SREBF2DYRK1AALDH1A1CDK5CDK5R1 | |
| SCHEMBL25362587 | 0.78 | HPGDS (0.55) | HPGDSSREBF2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL21682898 | 0.78 | LMNA (0.48) | SREBF2CDK5CDK5R1KDM4EMAPK1 | |
| SCHEMBL31341023 | 0.78 | CDK5 (0.44) | HPGDSSREBF2GSK3BDYRK1ACDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743081-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025019407-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-23 | — | — | WO | disclosed |