Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31341013 | 0.83 | ALDH1A1 (0.42) | POLBALDH1A1KDM4E | |
| SCHEMBL6444656 | 0.82 | CYP1A2 (0.45) | RAB9ANPC1NPSR1POLBALDH1A1 | |
| SCHEMBL31340929 | 0.75 | RAB9A (0.48) | RAB9AMAPTNPC1NPSR1POLB | |
| SCHEMBL13144514 | 0.75 | MAPT (0.70) | RAB9AMAPTNPC1NPSR1POLB | |
| SCHEMBL31341078 | 0.73 | ALDH1A1 (0.33) | RAB9AMAPTNPC1NPSR1ALDH1A1 | |
| SCHEMBL31341051 | 0.73 | BACE1 (0.38) | MAPTGAA | |
| SCHEMBL31341034 | 0.72 | SREBF2 (0.36) | MAPTGAA | |
| SCHEMBL31163885 | 0.72 | RAB9A (0.69) | RAB9AMAPTNPC1NPSR1POLB | |
| SCHEMBL3103929 | 0.72 | MAPT (0.56) | RAB9AMAPTNPC1NPSR1POLB | |
| SCHEMBL318924 | 0.71 | RAB9A (0.57) | RAB9AMAPTNPC1NPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743081-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025019407-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-23 | — | — | WO | disclosed |