Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341056 | 0.77 | RAB9A (0.50) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL31340972 | 0.75 | RAB9A (0.49) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL13144514 | 0.74 | MAPT (0.70) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL20541569 | 0.72 | GPR119 (0.56) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL4724385 | 0.72 | RAB9A (0.46) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL10436784 | 0.71 | KMT2A (0.56) | RAB9ANPC1MAPTPOLBRXFP1 | |
| SCHEMBL25360717 | 0.70 | RAB9A (0.57) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL27107644 | 0.70 | HPGDS (0.56) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL31341048 | 0.70 | RAB9A (0.57) | RAB9ANPC1MAPTPOLBPKM | |
| SCHEMBL595943 | 0.70 | RAB9A (0.54) | RAB9ANPC1MAPTPOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743081-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025019407-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-23 | — | — | WO | disclosed |