Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | FOS | P01100 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31340873 | 0.94 | SYK (0.40) | SYKALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL25122796 | 0.86 | ALDH1A1 (0.41) | SYKALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL27224889 | 0.81 | JAK1 (0.44) | SYKALDH1A1MEN1KMT2AMERTK | |
| SCHEMBL30990814 | 0.79 | MEN1 (0.42) | SYKALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL31465490 | 0.73 | ALDH1A1 (0.40) | SYKALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL22348019 | 0.73 | MEN1 (0.44) | SYKALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL29391314 | 0.73 | MEN1 (0.44) | SYKALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL27166380 | 0.71 | MEN1 (0.45) | SYKMEN1KMT2AMERTKTDP1 | |
| SCHEMBL4405587 | 0.69 | ALDH1A1 (0.63) | SYKALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL574167 | 0.67 | ALDH1A1 (0.60) | SYKALDH1A1MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049247-A1 | 5,6-CORE SILACYCLE BASED INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND APPLICATION IN GENE EDITING | JUNO THERAPEUTICS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |