Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Aziridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aziridine SCHEMBL28405709 | 1.00 | — | — | |
| Bromide SCHEMBL3966683 | 0.93 | HIF1A (0.86) | — | |
| Piperazine SCHEMBL1005659 | 0.93 | — | — | |
| Piperazine SCHEMBL1224331 | 0.93 | — | — | |
| Bromide SCHEMBL6017046 | 0.93 | HIF1A (0.86) | — | |
| Piperazine SCHEMBL1005658 | 0.93 | HIF1A (0.86) | — | |
| Aziridine SCHEMBL16878816 | 0.91 | — | — | |
| Aziridine SCHEMBL2267 | 0.91 | — | — | |
| Aziridine SCHEMBL3089497 | 0.91 | — | — | |
| Piperazine SCHEMBL5380983 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115117247-A | Perovskite solar cell and preparation method thereof | 中国科学技术大学 | 2022-09-27 | — | — | CN | claimed |
| CN-119708140-A | Peptide compounds and methods of treating diseases | 免疫制药有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119708143-A | Peptide compounds and methods of treating diseases | 免疫制药有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119708142-A | Peptide compounds and methods of treating diseases | 免疫制药有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119708141-A | Peptide compounds and methods of treating diseases | 免疫制药有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119708144-A | Peptide compounds and methods of treating diseases | 免疫制药有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-115942948-B | Peptide compounds and methods of treating diseases | 免疫制药有限公司 | 2025-01-14 | — | — | CN | disclosed |
| CN-115117247-B | Perovskite solar cell and preparation method thereof | 中国科学技术大学 | 2024-04-16 | — | — | CN | disclosed |
| CN-115117247-A | Perovskite solar cell and preparation method thereof | 中国科学技术大学 | 2022-09-27 | — | — | CN | disclosed |
| US-10556873-B2 | Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using | ILLINOIS INSTITUTE OF TECHNOLOGY (US) | 2020-02-11 | — | — | US | disclosed |
| US-20190175633-A1 | REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS | IONOVATION GMBH (DE) | 2019-06-13 | — | — | US | disclosed |
| US-10189803-B2 | Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions | ILLINOIS INSTITUTE OF TECHNOLOGY (US) | 2019-01-29 | — | — | US | disclosed |
| US-20170008863-A1 | SYNTHESIS OF THERAPEUTIC AND DIAGNOSTIC DRUGS CENTERED ON REGIOSELECTIVE AND STEREOSELECTIVE RING OPENING OF AZIRIDINIUM IONS | CHONG, HYUN-SOON, PHD | 2017-01-12 | — | — | US | disclosed |
| US-20160052894-A1 | BIMODAL LIGANDS WITH MACROCYCLIC AND ACYCLIC BINDING MOIETIES, COMPLEXES AND COMPOSITIONS THEREOF, AND METHODS OF USING | CHONG, HYUN-SOON, PHD | 2016-02-25 | — | — | US | disclosed |
| US-20150240295-A1 | REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS | IONOVATION GMBH (DE) | 2015-08-27 | — | — | US | disclosed |
| US-9115094-B2 | Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using | THE UNITED STATES OF AMERICA, NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS) (US) | 2015-08-25 | — | — | US | disclosed |
| EP-2900681-A1 | REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS | Ionovation GmbH (DE) | 2015-08-05 | — | — | EP | disclosed |
| US-20100322855-A1 | Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using | ILLINOIS INSTITUTE OF TECHNOLOGY (US) | 2010-12-23 | — | — | US | disclosed |
| WO-2010011367-A2 | BIMODAL LIGANDS WITH MACROCYCLIC AND ACYCLIC BINDING MOIETIES, COMPLEXES AND COMPOSITIONS THEREOF, AND METHODS OF USING | ILLINOIS INSTITUTE OF TECHNOLOGY (US) | 2010-01-28 | — | — | WO | disclosed |
| CN-1261873-A | Methods and compositions for selectively modifying nucleic acids | PENTOSE PHARMACEUTICALS INC (US) | 2000-08-02 | — | — | CN | disclosed |