Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3123309 | 0.90 | ADRB2 (0.54) | POLBADRB2ALDH1A1LMNAMAPT | |
| SCHEMBL3263934 | 0.85 | POLB (0.42) | POLBADRB2ALDH1A1LMNAMAPT | |
| SCHEMBL3263761 | 0.83 | POLB (0.46) | POLBADRB2ALDH1A1LMNAMAPT | |
| SCHEMBL1003852 | 0.83 | POLB (0.52) | POLBADRB2ALDH1A1LMNAMAPT | |
| SCHEMBL10472998 | 0.82 | ADRB2 (0.57) | POLBADRB2ALDH1A1BAZ2BBAZ2A | |
| SCHEMBL3135458 | 0.82 | STAT3 (0.47) | POLBADRB2ALDH1A1LMNAMAPT | |
| SCHEMBL3128196 | 0.81 | ADRB2 (0.46) | POLBADRB2ALDH1A1LMNAMAPT | |
| SCHEMBL8435344 | 0.81 | ADRB2 (0.60) | POLBADRB2ALDH1A1BAZ2BBAZ2A | |
| SCHEMBL4564641 | 0.80 | ADRB2 (0.57) | POLBADRB2ALDH1A1HPGDCHRM2 | |
| SCHEMBL9688340 | 0.80 | ADRB2 (0.45) | POLBADRB2ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2128160-B1 | Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents | UNIV DUISBURG ESSEN (DE) | 2010-07-14 | — | — | EP | disclosed |
| EP-2128160-A1 | Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents | Universität Duisburg-Essen (DE) | 2009-12-02 | — | — | EP | disclosed |