Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.50 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL14247346 | 1.00 | NFE2L2 (0.50) | NFE2L2PTGES2CA1CA2CA9 | |
| SCHEMBL789817 | 0.92 | NFE2L2 (0.52) | NFE2L2PTGES2CA1CA2CA9 | |
| SCHEMBL29705304 | 0.92 | NFE2L2 (0.52) | NFE2L2PTGES2CA1CA2CA9 | |
| Trifluoroacetic Acid SCHEMBL14247260 | 0.82 | NFE2L2 (0.48) | NFE2L2PTGES2CA1CA2CA9 | |
| Formic Acid SCHEMBL14247786 | 0.80 | CA1 (0.50) | CA1CA2CA9MAPK1FTO | |
| SCHEMBL27553171 | 0.78 | NFE2L2 (0.52) | NFE2L2PTGES2CA1CA2SLC22A12 | |
| SCHEMBL31029569 | 0.78 | PTGES2 (0.57) | NFE2L2PTGES2CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL28312857 | 0.77 | NFE2L2 (0.51) | NFE2L2PTGES2CA1CA2SLC22A12 | |
| SCHEMBL30862874 | 0.76 | NFE2L2 (0.54) | NFE2L2PTGES2CA1CA2SLC22A12 | |
| SCHEMBL14247634 | 0.76 | CA1 (0.51) | PTGES2CA1CA2CA9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043350-A1 | TRIAZOLOPYRIDOPYRIMIDINE AND DIHYDROIMIDAZOPYRIDOPYRIMIDINE DERIVATIVES AS INHIBITORS OF THE GCN2 KINASE, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2025-03-06 | — | — | WO | disclosed |