Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.52 |
| ▸ | CA1 | P00915 | 5/20 | 0.51 |
| ▸ | CA2 | P00918 | 5/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29705304 | 1.00 | NFE2L2 (0.52) | NFE2L2CA1CA2CA9MAPK1 | |
| Formic Acid SCHEMBL31344342 | 0.92 | NFE2L2 (0.50) | NFE2L2CA1CA2CA9MAPK1 | |
| Formic Acid SCHEMBL14247346 | 0.92 | NFE2L2 (0.50) | NFE2L2CA1CA2CA9MAPK1 | |
| Trifluoroacetic Acid SCHEMBL14247260 | 0.87 | NFE2L2 (0.48) | NFE2L2CA1CA2CA9MAPK1 | |
| SCHEMBL31029569 | 0.85 | PTGES2 (0.57) | NFE2L2CA1CA2CA9MAPK1 | |
| SCHEMBL30862874 | 0.83 | NFE2L2 (0.54) | NFE2L2CA1CA2PTGES2SLC22A12 | |
| SCHEMBL14247634 | 0.82 | CA1 (0.51) | CA1CA2CA9MAPK1PTGES2 | |
| SCHEMBL10730949 | 0.82 | CA1 (0.45) | NFE2L2CA1CA2CA9MAPK1 | |
| SCHEMBL7867107 | 0.81 | TRPV4 (0.63) | NFE2L2CA1CA2PTGES2SLC22A12 | |
| SCHEMBL30504923 | 0.81 | TRPV4 (0.63) | NFE2L2CA1CA2PTGES2SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630529-B2 | GCN2 modulator compounds | Alesta Therapeutics BV (NL) | 2026-05-19 | — | — | US | claimed |
| CN-119661503-A | 4-Ethynyl pyridine derivatives as GCN2 inhibitors | IP2IPO创新有限公司 | 2025-03-21 | — | — | CN | claimed |
| EP-4522610-A1 | GCN2 INHIBITORR | IP2IPO Innovations Limited (GB) | 2025-03-19 | — | — | EP | claimed |
| CN-119451955-A | GCN2 inhibitors | IP2IPO创新有限公司 | 2025-02-14 | — | — | CN | claimed |
| US-20240150345-A1 | GCN2 MODULATING COMPOUNDS AND USES THEREOF | PHARMARON UK LTD. (GB) | 2024-05-09 | — | — | US | claimed |
| WO-2023218195-A1 | GCN2 INHIBITORR | IP2IPO INNOVATIONS LIMITED (GB) | 2023-11-16 | — | — | WO | claimed |
| CN-116113629-A | 4-ethynyl pyridine derivatives as GCN2 inhibitors | IP2IPO创新有限公司 | 2023-05-12 | — | — | CN | claimed |
| US-20230143059-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2023-05-11 | — | — | US | claimed |
| CN-109790122-B | Heterocyclic compounds | 武田药品工业株式会社 | 2022-06-24 | — | — | CN | claimed |
| EP-1879877-A2 | ANTIMICROBIAL AGENTS | Ranbaxy Laboratories Limited (IN) | 2008-01-23 | — | — | EP | claimed |
| WO-2006117762-A2 | ANTIMICROBIAL AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2006-11-09 | — | — | WO | claimed |
| US-12630529-B2 | GCN2 modulator compounds | Alesta Therapeutics BV (NL) | 2026-05-19 | — | — | US | disclosed |
| US-20250205232-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-06-26 | — | — | US | disclosed |
| CN-119677727-A | GCN2 modulator compounds | 阿莱斯塔治疗公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-119661503-A | 4-Ethynyl pyridine derivatives as GCN2 inhibitors | IP2IPO创新有限公司 | 2025-03-21 | — | — | CN | disclosed |
| WO-2012174312-A2 | BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012087938-A1 | QUINAZOLINONE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| US-4690707-A | PRE- AND POSTEMERGENCE HERBICIDES; PLANT GROWTH REGULATORS; PREFERENTIAL | CIBA-GEIGY CORPORATION (US) | 1987-09-01 | — | — | US | disclosed |
| US-4579583-A | HERBICIDES, GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1986-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12630529-B2 | GCN2 modulator compounds | NR3C1, GCN1, EIF2AK4 | NFE2L2 459/4885CA1 3553/4885CA2 1341/4885 |
| US-20250205232-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1B, SLC26A4 | NFE2L2 2095/4885CA1 4843/4885CA2 1067/4885 |
| US-20230143059-A1 | GCN2 MODULATOR COMPOUNDS | EIF2AK4, GPR119, GCN1 | NFE2L2 255/4885CA1 4675/4885CA2 2579/4885 |
| US-20240150345-A1 | GCN2 MODULATING COMPOUNDS AND USES THEREOF | EIF2AK4, GCN1, CLN6 | NFE2L2 353/4885CA1 4590/4885CA2 4232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.