SCHEMBL31345733

SCHEMBL31345733

NNC(=O)c1cc(N)ccn1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 6/20 0.50
KDM4E B2RXH2 4/20 0.42
MPO P05164 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2A6 P11509 1/20 0.42
CYP2C19 P33261 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.42
ALDH1A1 P00352 3/20 0.41
MAPT P10636 3/20 0.41
TDP1 Q9NUW8 1/20 0.41
GAA P10253 1/20 0.40
SMYD3 Q9H7B4 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27212647 1.00 P2RX7 (0.50) P2RX7KDM4EMPOCYP1A2CYP3A4
SCHEMBL14897896 0.85 KDM4D (0.50) KDM4ELOXL2ALDH1A1MAPTHDAC3
SCHEMBL2642841 0.83 KDR (0.46) KDM4ECYP1A2CYP3A4CYP2C19ALDH1A1
SCHEMBL19462304 0.82 PARP1 (0.44) KDM4ELOXL2SMYD3
SCHEMBL7171815 0.81 KDM4E (0.57) P2RX7KDM4EMPOCYP1A2CYP3A4
SCHEMBL17850259 0.81 P2RX7 (0.50) P2RX7KDM4EMPOCYP1A2CYP3A4
SCHEMBL31538151 0.80 KDM4C (0.38) KDM4ELOXL2ALDH1A1MAPTGAA
SCHEMBL14882720 0.80 SMYD3 (0.39) KDM4ELOXL2MAPTGAASMYD3
SCHEMBL1054692 0.79 KDM4C (0.58) P2RX7KDM4ECYP1A2ALDH1A1MAPT
SCHEMBL17596266 0.79 P2RX7 (0.49) P2RX7KDM4EMPOCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119569701-A Preparation and application of compound with 1H-benzimidazole structure 江西中医药大学 2025-03-07 CN disclosed