SCHEMBL31345987

SCHEMBL31345987

Cc1cc(Br)nc(C2Cc3cc(C(F)(F)F)ccc3O2)c1

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TERT O14746 1/20 0.35
TEAD1 P28347 8/20 0.34
PIK3CA P42336 1/20 0.32
PIK3CB P42338 1/20 0.32
PIK3CG P48736 1/20 0.32
CASP3 P42574 1/20 0.31
CASP7 P55210 1/20 0.31
CASP8 Q14790 1/20 0.31
HRH3 Q9Y5N1 1/20 0.31
KDM1A O60341 1/20 0.31
PNMT P11086 3/20 0.31
PPARD Q03181 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31346051 0.83 TEAD1 (0.37) TEAD1CASP3CASP7CASP8KDM1A
SCHEMBL31346047 0.83 TEAD1 (0.37) TEAD1CASP3CASP7CASP8KDM1A
SCHEMBL31345972 0.83 CTSS (0.35) TERTPIK3CAPIK3CBPIK3CGCASP3
SCHEMBL31346133 0.79 NPSR1 (0.33) TERTCASP3CASP7CASP8PPARD
SCHEMBL31346033 0.79 TERT (0.33) TERTPIK3CAPIK3CBPIK3CGHRH3
SCHEMBL31346060 0.78 TERT (0.34) TERTTEAD1HRH3PNMT
SCHEMBL31346038 0.78 TERT (0.34) TERTTEAD1HRH3PNMT
SCHEMBL31346056 0.77 TEAD1 (0.34) TERTTEAD1CASP3CASP7CASP8
SCHEMBL31346045 0.73 TEAD1 (0.37) TEAD1PNMT
SCHEMBL31345984 0.73 PNMT (0.35) TEAD1HRH3PNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed