SCHEMBL31346136

SCHEMBL31346136

FC(F)(F)c1ccc2c(c1)CC(c1cncc(Br)c1)O2

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 7/20 0.40
CYP11B2 P19099 7/20 0.40
HSD17B10 Q99714 1/20 0.36
TEAD1 P28347 2/20 0.33
PNMT P11086 4/20 0.32
AADAT Q8N5Z0 1/20 0.32
GRIN1 Q05586 1/20 0.31
GRIN2B Q13224 1/20 0.31
PRKAB2 O43741 1/20 0.31
PRKAG1 P54619 1/20 0.31
PRKAA2 P54646 1/20 0.31
PRKAA1 Q13131 1/20 0.31
PRKAG3 Q9UGI9 1/20 0.31
PRKAG2 Q9UGJ0 1/20 0.31
PRKAB1 Q9Y478 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31345984 0.85 PNMT (0.35) TEAD1PNMTAADAT
SCHEMBL31345963 0.82 TEAD1 (0.42) TEAD1
SCHEMBL31346002 0.82 TEAD1 (0.42) TEAD1
SCHEMBL31346029 0.82 CYP11B1 (0.40) CYP11B1CYP11B2GRIN1GRIN2B
SCHEMBL31345979 0.81 CYP11B1 (0.44) CYP11B1CYP11B2HSD17B10
SCHEMBL31346022 0.81 FFAR1 (0.39) TEAD1PNMT
SCHEMBL31346038 0.80 TERT (0.34) TEAD1PNMT
SCHEMBL31346060 0.80 TERT (0.34) TEAD1PNMT
SCHEMBL31346045 0.78 TEAD1 (0.37) TEAD1PNMT
SCHEMBL31346056 0.76 TEAD1 (0.34) TEAD1PNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed