SCHEMBL31346145

SCHEMBL31346145

FC(F)(F)c1cc(Cl)c2c(c1)CC(c1cccc(Br)n1)O2

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TEAD1 P28347 2/20 0.33
RAB9A P51151 2/20 0.31
HPGD P15428 1/20 0.31
THRB P10828 1/20 0.30
KDM1A O60341 1/20 0.30
CBFB Q13951 1/20 0.30
NPC1 O15118 1/20 0.30
MAPT P10636 1/20 0.30
NFKB1 P19838 1/20 0.30
NFKB2 Q00653 1/20 0.30
RELA Q04206 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31346083 1.00 TEAD1 (0.33) TEAD1RAB9AHPGDTHRBKDM1A
SCHEMBL31346141 0.84 EZH2 (0.38)
SCHEMBL31346003 0.83 CTSS (0.42)
SCHEMBL31346051 0.80 TEAD1 (0.37) TEAD1KDM1A
SCHEMBL31346047 0.80 TEAD1 (0.37) TEAD1KDM1A
SCHEMBL31345969 0.79 CBFB (0.32) CBFB
SCHEMBL31345985 0.79 TEAD1 (0.37) TEAD1THRBKDM1A
SCHEMBL31345970 0.74 TTR (0.32)
SCHEMBL31346074 0.72 DPP4 (0.30)
SCHEMBL31346162 0.71 CYP19A1 (0.45) TEAD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed