SCHEMBL31346154

SCHEMBL31346154

O=C(O)c1cccc(C2Cc3cc(Cl)c(Cl)cc3O2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
KMO O15229 2/20 0.43
FFAR1 O14842 2/20 0.43
TDP1 Q9NUW8 1/20 0.42
PARP1 P09874 1/20 0.40
AR P10275 1/20 0.39
KDM4E B2RXH2 2/20 0.39
MEN1 O00255 2/20 0.39
GAA P10253 2/20 0.39
KMT2A Q03164 2/20 0.39
LTA4H P09960 1/20 0.39
PLA2G1B P04054 1/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ATG4B Q9Y4P1 1/20 0.39
CYP19A1 P11511 2/20 0.39
TTR P02766 1/20 0.38
TSHR P16473 1/20 0.38
MCL1 Q07820 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31345983 0.90 ALDH1A1 (0.45) ALDH1A1KMOFFAR1TDP1PARP1
SCHEMBL31346172 0.86 ALDH1A1 (0.48) ALDH1A1KMOFFAR1TDP1PARP1
SCHEMBL31346017 0.84 ALDH1A1 (0.41) ALDH1A1KMOFFAR1TDP1PARP1
SCHEMBL31345958 0.78 KDM1A (0.38) FFAR1CYP19A1TTR
SCHEMBL31346052 0.78 TDP1 (0.47) ALDH1A1KMOFFAR1TDP1AR
SCHEMBL31346099 0.78 CFTR (0.49) ALDH1A1KMOFFAR1TDP1AR
SCHEMBL31346163 0.78 TDP1 (0.47) ALDH1A1KMOFFAR1TDP1PARP1
SCHEMBL31345978 0.78 CFTR (0.49) ALDH1A1KMOFFAR1TDP1AR
SCHEMBL31346151 0.78 CFTR (0.49) ALDH1A1KMOFFAR1MRGPRX4
SCHEMBL31346020 0.75 LDHA (0.49) FFAR1CYP19A1TTRTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed