Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 3/20 | 0.36 |
| ▸ | FPR2 | P25090 | 2/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31348258 | 1.00 | PDE2A (0.40) | PDE2ADRD2GRIN2BGRM2SLC18A3 | |
| SCHEMBL31348114 | 0.91 | PDE2A (0.38) | PDE2ADRD2SLC18A3CCR2FPR2 | |
| SCHEMBL31348140 | 0.84 | DRD2 (0.55) | DRD2GRIN2BGRM2SLC18A3CCR2 | |
| SCHEMBL31348261 | 0.82 | SCN1A (0.43) | DRD2SCN1ASCN5ASCN9A | |
| SCHEMBL31348262 | 0.74 | DRD4 (0.49) | DRD2GRM2SLC18A3KCNH2 | |
| SCHEMBL15591909 | 0.70 | CHRNB2 (0.49) | PDE2ASIGMAR1 | |
| SCHEMBL31348186 | 0.68 | OPRL1 (0.46) | DRD2SIGMAR1 | |
| SCHEMBL31348178 | 0.68 | DRD4 (0.43) | DRD2GRM2KCNH2 | |
| SCHEMBL31348113 | 0.68 | OPRL1 (0.46) | DRD2SIGMAR1 | |
| SCHEMBL31348167 | 0.67 | HTR2B (0.44) | DRD2GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025006982-A1 | POTENT AND SELECTIVE DOPAMINE D3 RECEPTOR ANTAGONISTS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2025-01-02 | — | — | WO | disclosed |