Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.31 |
| ▸ | IL1B | P01584 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31349496 | 0.82 | HCAR1 (0.39) | HCAR1TGFBR1GPR119EPHX2RIPK1 | |
| SCHEMBL31349486 | 0.81 | HCAR1 (0.38) | USP30HCAR1TGFBR1GPR119EPHX2 | |
| SCHEMBL31349536 | 0.81 | MAP3K12 (0.32) | — | |
| SCHEMBL31349450 | 0.78 | ABL1 (0.36) | — | |
| SCHEMBL31349483 | 0.76 | EPHX2 (0.38) | HCAR1TGFBR1GPR119EPHX2RIPK1 | |
| SCHEMBL25150914 | 0.75 | USP30 (0.47) | USP30HCAR1GPR119BACE1IL1B | |
| SCHEMBL25151102 | 0.73 | HCAR1 (0.45) | USP30HCAR1GPR119BACE1 | |
| SCHEMBL25150871 | 0.73 | USP30 (0.46) | USP30HCAR1GPR119BACE1 | |
| SCHEMBL18136675 | 0.73 | USP30 (0.51) | USP30HCAR1BACE1 | |
| SCHEMBL2146825 | 0.71 | USP30 (0.44) | USP30GPR119BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743078-A2 | APOL1 INHIBITORS AND METHODS OF USE | Maze Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015104-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |