Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orthocresol SCHEMBL1232540 | 0.78 | TRPA1 (0.46) | MEN1LMNAKMT2APOLBKDM4E | |
| Tromethamine SCHEMBL7196402 | 0.78 | MEN1 (0.42) | MEN1LMNAKMT2APOLBKDM4E | |
| SCHEMBL67348 | 0.78 | — | — | |
| Tromethamine SCHEMBL7757710 | 0.76 | CA1 (0.41) | LMNAPOLBKDM4ETSHRTAAR1 | |
| SCHEMBL3563862 | 0.75 | TSHR (0.53) | LMNATSHRACHETAAR1CYP3A4 | |
| SCHEMBL22472034 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL5076752 | 0.75 | — | — | |
| Bromide SCHEMBL3712596 | 0.75 | — | — | |
| SCHEMBL7947978 | 0.75 | — | — | |
| Iodide SCHEMBL7953647 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116997544-A | New process for the synthesis of 5- { 5-chloro-2- [ (3S) -3- [ (morpholin-4-yl) methyl ] -3, 4-dihydroisoquinoline-2 (1H) -carbonyl ] phenyl } -1, 2-dimethyl-1H-pyrrole-3-carboxylic acid derivatives and their use in the production of pharmaceutical compounds | 法国施维雅药厂 | 2023-11-03 | — | — | CN | claimed |
| US-11505542-B2 | Preparation method for morpholinquinazoline compound and intermediates thereof | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD (CN) | 2022-11-22 | — | — | US | claimed |
| US-20260070867-A1 | BINAPHTHYL COMPOUNDS AND THERMOPLASTIC RESINS | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2026-03-12 | — | — | US | disclosed |
| CN-113747924-B | Antibody-drug conjugates and uses thereof | ABL生物公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-117715917-A | Photoactive non-fullerene receptors of the a-D-a' -D-a type for use in optoelectronic devices | 住友化学株式会社 | 2024-03-15 | — | — | CN | disclosed |
| CN-116997544-A | New process for the synthesis of 5- { 5-chloro-2- [ (3S) -3- [ (morpholin-4-yl) methyl ] -3, 4-dihydroisoquinoline-2 (1H) -carbonyl ] phenyl } -1, 2-dimethyl-1H-pyrrole-3-carboxylic acid derivatives and their use in the production of pharmaceutical compounds | 法国施维雅药厂 | 2023-11-03 | — | — | CN | disclosed |
| CN-111094223-B | binaphthyl compounds | 罗伊特化学仪器制造公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-109791987-B | Organic semiconductor compound | 天光材料科技股份有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-109891616-B | Organic semiconductor compound | 天光材料科技股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-109804481-B | Organic photodetector | 天光材料科技股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-109311784-B | Material for organic electroluminescent device | 默克专利有限公司 | 2022-03-25 | — | — | CN | disclosed |
| EP-1153017-A1 | BICYCLIC COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR LIGANDS | Aventis Pharma Limited (GB) | 2001-11-14 | — | — | EP | disclosed |
| EP-1140950-A1 | PREPARATION OF MONO- AND DI-ARYLPHOSPHINES | CYTEC TECHNOLOGY CORP. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2001064640-A1 | 2,3-DIHYDRO-1H-INDOLINYL-ALKANOIC ACIDS AS CELL ADHESION INHIBITORS | AVENTIS PHARMA LIMITED (GB) | 2001-09-07 | — | — | WO | disclosed |
| WO-2000049005-A1 | BICYCLIC COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR LIGANDS | AVENTIS PHARMA LIMITED (GB) | 2000-08-24 | — | — | WO | disclosed |
| WO-2000032613-A1 | PREPARATION OF MONO- AND DI-ARYLPHOSPHINES | CYTEC TECHNOLOGY CORP. (US) | 2000-06-08 | — | — | WO | disclosed |
| US-5948915-A | Cyclobutenedione derivative, manufacturing method thereof and non-linear optical device containing the same | FUJI XEROX CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0742242-B1 | Process for the copolymerization of carbon monoxide with an olefinically unsaturated compound | SHELL INT RESEARCH (NL) | 1999-08-25 | — | — | EP | disclosed |
| EP-0788511-A1 | CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996011210-A1 | CYCLIC HEXAPEPTIDES HAVING ANTIBIOTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260070867-A1 | BINAPHTHYL COMPOUNDS AND THERMOPLASTIC RESINS | CBR1, CBR3, SCO2 | MEN1 4170/4885LMNA 3108/4885KMT2A 1853/4885 |
| US-11505542-B2 | Preparation method for morpholinquinazoline compound and intermediates thereof | MDK, MYLK4, MYLK3 | MEN1 143/4885LMNA 3759/4885KMT2A 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.