SCHEMBL31350362

SCHEMBL31350362

O=C(NCc1cccc(O)n1)c1c(C(F)F)sc2cccc(OCc3ccccc3)c12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SGMS2 Q8NHU3 2/20 0.40
MAPT P10636 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
LMNA P02545 1/20 0.39
KMT2A Q03164 2/20 0.39
MMP13 P45452 1/20 0.38
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
SENP5 Q96HI0 6/20 0.36
SENP2 Q9HC62 6/20 0.36
SENP1 Q9P0U3 6/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31350336 0.86 SGMS2 (0.42) SGMS2MAPTL3MBTL1LMNAKMT2A
SCHEMBL30656210 0.82 EDNRA (0.42) MMP13SENP5SENP2SENP1NPC1
SCHEMBL31350326 0.81 MEN1 (0.43) SGMS2MAPTL3MBTL1LMNAKMT2A
SCHEMBL31350393 0.80 FOLH1 (0.46) MAPTL3MBTL1KMT2ANPC1MEN1
SCHEMBL31350321 0.80 ALDH1A1 (0.44) SGMS2LMNAKMT2AHPGDSMN1; SMN2
SCHEMBL31350355 0.76 SLC6A5 (0.51) LMNAKMT2A
SCHEMBL31350332 0.75 MEN1 (0.42) SGMS2KMT2ANPC1MEN1
SCHEMBL31350333 0.75 NOTUM (0.41) SGMS2MAPTLMNANPC1RAB9A
SCHEMBL31350360 0.75 CD274 (0.36) SGMS2MAPTL3MBTL1LMNAKMT2A
SCHEMBL31350328 0.73 BRD4 (0.45) SGMS2KMT2AMEN1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119421879-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN claimed
CN-119421879-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN disclosed