Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 6/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128132 | 0.78 | GRIA2 (0.42) | GRIA4GRIA2GAAALDH1A1HSD17B10 | |
| SCHEMBL3139160 | 0.76 | GRIA4 (0.80) | GRIA4GRIA2ALDH1A1L3MBTL1HSP90AB1 | |
| SCHEMBL3135106 | 0.74 | GRIA2 (0.39) | GRIA4GRIA2GAAALDH1A1HSD17B10 | |
| SCHEMBL6772083 | 0.68 | GRIA4 (0.53) | GRIA4GRIA2GAAALDH1A1HSD17B10 | |
| SCHEMBL3138044 | 0.67 | GRIA4 (0.52) | GRIA4GRIA2ALDH1A1HSD17B10TSHR | |
| SCHEMBL1720715 | 0.67 | ALDH1A1 (0.51) | GAAALDH1A1HSD17B10TSHRMAPK1 | |
| SCHEMBL3134036 | 0.66 | GRIA4 (1.00) | GRIA4GRIA2KMT2A | |
| SCHEMBL8281925 | 0.66 | GRIA4 (0.70) | GRIA4GRIA2KMT2A | |
| SCHEMBL3128683 | 0.66 | L3MBTL1 (0.56) | GAAALDH1A1HSD17B10TSHRMAPK1 | |
| SCHEMBL3128645 | 0.66 | GRIA4 (0.54) | GRIA4GRIA2ALDH1A1L3MBTL1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642361-B2 | Thiophene and furan compounds | ELI LILLY AND COMPANY (US) | 2010-01-05 | — | — | US | disclosed |
| US-20070105852-A1 | Thiophene and furan compounds | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105852-A1 | Thiophene and furan compounds | PSEN2, PSEN1, TPMT | GRIA4 15/4885GRIA2 57/4885GAA 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.