SCHEMBL31356226

SCHEMBL31356226

O=C1CCC(Nc2cccc(NCc3ccc(CN4CCCCC4)c(F)c3)c2)C(=O)N1

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 18/20 0.66
▸ CRBN Q96SW2 18/20 0.66
▸ KDM4E B2RXH2 2/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31355906 0.92 DDB1 (0.58) DDB1CRBNKDM4ESMN1; SMN2
SCHEMBL31355766 0.91 CRBN (0.54) DDB1CRBN
SCHEMBL31356182 0.88 DDB1 (0.77) DDB1CRBN
SCHEMBL31355867 0.87 DDB1 (0.49) DDB1CRBNKDM4ESMN1; SMN2
SCHEMBL31355880 0.83 CRBN (0.47) DDB1CRBN
SCHEMBL31356206 0.83 DDB1 (0.61) DDB1CRBN
SCHEMBL31356060 0.81 CRBN (0.44) DDB1CRBNKDM4ESMN1; SMN2
SCHEMBL31355762 0.81 DDB1 (0.44) DDB1CRBNKDM4ESMN1; SMN2
SCHEMBL31356243 0.80 CRBN (0.62) DDB1CRBN
SCHEMBL21965407 0.80 DDB1 (1.00) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025026422-A1 ARYL OR HETEROARYL SUBSTITUTED GLUTARIMIDE DERIVATIVE AND USE THEREOF 标新生物医药科技(上海)有限公司 2025-02-06 — — WO claimed
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