SCHEMBL31359710

SCHEMBL31359710

COc1c(Cl)ncc2cnn(COCC[Si](C)(C)C)c12

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 6/20 0.34
HSP90AA1 P07900 1/20 0.31
TRAP1 Q12931 1/20 0.31
HTR2A P28223 1/20 0.30
HTR2C P28335 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31359685 0.85 DGAT1 (0.34) DGAT1
SCHEMBL25758167 0.78 HTR2A (0.35) HSP90AA1TRAP1HTR2AHTR2C
SCHEMBL24344356 0.78 DGAT1 (0.36) DGAT1HTR2AHTR2C
SCHEMBL25049226 0.77 DGAT1 (0.34) DGAT1HTR2AHTR2C
SCHEMBL30498388 0.76 HTR2A (0.34) HSP90AA1TRAP1HTR2AHTR2C
SCHEMBL27199332 0.76 HTR2A (0.34) HSP90AA1TRAP1HTR2AHTR2C
SCHEMBL25758951 0.75 LRRK2 (0.34) HSP90AA1TRAP1HTR2AHTR2C
SCHEMBL31138676 0.74 TUBB4A (0.32) DGAT1
SCHEMBL20262422 0.74 DGAT1 (0.33) DGAT1
SCHEMBL23292060 0.73 DGAT1 (0.34) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727935-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF Lynk Pharmaceuticals Co. Ltd. (CN) 2026-04-22 EP disclosed
WO-2024255886-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-12-19 WO disclosed
WO-2024254832-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-12-19 WO disclosed