SCHEMBL31361149

SCHEMBL31361149

CC(F)(F)c1ccc(Cl)nc1F

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21718901 0.85 CYP3A4 (0.30) CYP11B1CYP11B2
SCHEMBL25411095 0.83 CYP11B2 (0.41) CYP11B1CYP11B2
SCHEMBL3509516 0.82 AR (0.33)
SCHEMBL16807808 0.75 IDH1 (0.32)
SCHEMBL13020871 0.69 CYP11B1 (0.35) CYP11B1CYP11B2
SCHEMBL23025975 0.69
SCHEMBL16256879 0.68 CYP11B1 (0.37) CYP11B1CYP11B2
SCHEMBL8017359 0.67
SCHEMBL29388275 0.67 XPO1 (0.46) CYP11B1CYP11B2
SCHEMBL855349 0.67 XPO1 (0.46) CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4746965-A1 BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS F. Hoffmann-La Roche AG (CH) 2026-05-27 EP disclosed
WO-2025017041-A1 BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2025-01-23 WO disclosed