SCHEMBL855349

SCHEMBL855349

FC(F)(F)c1ccc(Cl)nc1Cl

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
XPO1 O14980 14/20 0.46
ADRB2 P07550 1/20 0.46
CYP11B1 P15538 1/20 0.39
CYP11B2 P19099 1/20 0.39
PIK3CD O00329 1/20 0.37
RPS6KA5 O75582 1/20 0.36
ALDH1A1 P00352 1/20 0.33
GRM2 Q14416 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29388275 1.00 XPO1 (0.46) XPO1ADRB2CYP11B1CYP11B2PIK3CD
SCHEMBL10749028 0.84 XPO1 (0.38) XPO1ADRB2CYP11B1CYP11B2
SCHEMBL29464871 0.82 PIK3CD (0.46) XPO1ADRB2PIK3CDRPS6KA5ALDH1A1
SCHEMBL1427778 0.82 PIK3CD (0.46) XPO1ADRB2PIK3CDRPS6KA5ALDH1A1
SCHEMBL23850283 0.79 XPO1 (0.41) XPO1ADRB2CYP11B1CYP11B2PIK3CD
SCHEMBL11010121 0.79 XPO1 (0.45) XPO1ADRB2CYP11B1CYP11B2PIK3CD
SCHEMBL25411095 0.79 CYP11B2 (0.41) XPO1ADRB2CYP11B1CYP11B2PIK3CD
SCHEMBL30285418 0.79 XPO1 (0.45) XPO1ADRB2CYP11B1CYP11B2PIK3CD
SCHEMBL31683787 0.78 CYP3A4 (0.43)
SCHEMBL4989070 0.78 CYP3A4 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 548 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114933852-A Electromagnetic wire of driving motor of electric sweeper and preparation method thereof 铜陵兢强电子科技股份有限公司 2022-08-23 CN claimed
EP-0078410-B1 PROCESS FOR PRODUCING 3-CHLORO-5-TRIFLUOROMETHYLPYRIDINES ISHIHARA SANGYO KAISHA, LTD. (JP) 1987-05-27 EP claimed
US-4490534-A CHLORINATION IN VAPOR PHASE, PRESENCE OF CATALYST ISHIHARA SANGYO KAISHA LTD. (JP) 1984-12-25 US claimed
US-4429132-A FROM 3-PICOLINE IN PRESENCE OF METAL OXIDE OR HALIDE CATALYST IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-01-31 US claimed
US-4420618-A CHLORINATION, METAL CHLORIDE CATALYST ISHIHARA SANGYO KAISHA LTD. (JP) 1983-12-13 US claimed
US-4417055-A Process for producing a β-trifluoromethylpyridine ISHIHARA SANGYO KAISHA LTD. (JP) 1983-11-22 US claimed
US-4393214-A Preparation of 2-chloro-5-trifluoromethylpyridine and 2-chloro-5-perchlorofluoromethylpyridines IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-07-12 US claimed
EP-0078410-A2 Process for producing 3-chloro-5-trifluoromethylpyridines ISHIHARA SANGYO KAISHA, LTD. (JP) 1983-05-11 EP claimed
EP-0065358-A1 Production of 3-trichloromethyl- and 3-trifluoromethyl-pyridines IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-24 EP claimed
US-4288599-A VAPOR PHASE HALOGENATION OF B-PICOLINE WITH CHLORINE AND HYDROGEN FLUORIDE ISHIHARA SANGYO KAISHA LTD. (JP) 1981-09-08 US claimed
US-4266064-A CATALYTIC FLUORINATION IN A VAPOR PHASE ISHIHARA SANGYO KAISHA LTD. (JP) 1981-05-05 US claimed
JP-56040667-A None JP disclosed
JP-55092368-A None JP disclosed
JP-55136263-A None JP disclosed
US-12630528-B2 Amino aryl derivative useful as diacylglycerol acyltransferase 2 inhibitor and use thereof LG CHEM, LTD. (KR) 2026-05-19 US disclosed
EP-0025363-A1 N-Benzoyl N'-pyridyloxy phenyl ureas, a process for their production and pharmaceutical and insecticidal compositions containing the same ISHIHARA SANGYO KAISHA LTD. (JP) 1981-03-18 EP disclosed
JP-S55136263-A PREPARATION OF 3-TRIFLUOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA LTD 1980-10-23 JP disclosed
EP-0013474-A2 Preparation of 2-chloro-5-trifluoromethylpyridine IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1980-07-23 EP disclosed
JP-S5592368-A PREPARATION OF 2-(4-SUBSTITUTED PHENOXY)-5-TRIFLUOROMETHYL PYRIDINE ISHIHARA SANGYO KAISHA LTD 1980-07-12 JP disclosed
US-3974166-A FUNGICIDE CIBA-GEIGY CORPORATION (US) 1976-08-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12630528-B2 Amino aryl derivative useful as diacylglycerol acyltransferase 2 inhibitor and use thereof DGAT2, DGAT1, SOAT2 XPO1 4789/4885ADRB2 277/4885CYP11B1 1000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.