SCHEMBL31361176

SCHEMBL31361176

Cc1cc(C#N)nn1-c1nc(Cl)ccc1OC1(C#N)CC1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
USP1 O94782 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31361119 0.83 KDM4E (0.38) KDM4EUSP1
SCHEMBL31361141 0.78 MBOAT4 (0.33) KDM4E
SCHEMBL31361210 0.78 USP1 (0.31) KDM4EUSP1
SCHEMBL31361121 0.78 POLB (0.32) KDM4EUSP1
SCHEMBL31361126 0.78 MBOAT4 (0.34) KDM4E
SCHEMBL31361202 0.77 GRM2 (0.33) KDM4E
SCHEMBL31078137 0.76 RPS6KA5 (0.40) KDM4E
SCHEMBL31361233 0.76
SCHEMBL31361218 0.76 MBOAT4 (0.32) USP1
SCHEMBL31361207 0.73 USP1 (0.35) KDM4EUSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4746965-A1 BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS F. Hoffmann-La Roche AG (CH) 2026-05-27 EP disclosed
WO-2025017041-A1 BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2025-01-23 WO disclosed