Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31361117 | 0.81 | KDM4E (0.38) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL31361145 | 0.75 | GRM2 (0.40) | KDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL25318266 | 0.74 | MEN1 (0.39) | KDM4ESMN1; SMN2HTTALDH1A1 | |
| SCHEMBL31153160 | 0.74 | MEN1 (0.39) | KDM4ESMN1; SMN2HTTALDH1A1 | |
| SCHEMBL31361174 | 0.72 | KDM4E (0.33) | KDM4EHTTALDH1A1 | |
| SCHEMBL31361215 | 0.72 | KDM4E (0.33) | KDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL3290485 | 0.66 | POLB (0.55) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL14665795 | 0.65 | MAPT (0.53) | KDM4ELMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL13172484 | 0.64 | KDM4E (0.58) | KDM4EHTT | |
| SCHEMBL31361207 | 0.64 | USP1 (0.35) | KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746965-A1 | BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025017041-A1 | BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-23 | — | — | WO | disclosed |