Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31361289 | 0.80 | GRM2 (0.40) | GRM2KDM4EHTTLMNATP53 | |
| SCHEMBL31361174 | 0.77 | KDM4E (0.33) | GRM2KDM4EHTTKMT2A | |
| SCHEMBL25318266 | 0.76 | MEN1 (0.39) | KDM4EHTTMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL31153160 | 0.76 | MEN1 (0.39) | KDM4EHTTMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL31361222 | 0.75 | KDM4E (0.36) | KDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL31361215 | 0.74 | KDM4E (0.33) | KDM4EHTTLMNASMN1; SMN2 | |
| SCHEMBL31361117 | 0.73 | KDM4E (0.38) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL31361244 | 0.71 | GRM2 (0.34) | GRM2KDM4ENOTUMAR | |
| SCHEMBL3290485 | 0.67 | POLB (0.55) | KDM4EHTTLMNAMAPK1KMT2A | |
| SCHEMBL2708931 | 0.66 | MBOAT4 (0.38) | GRM2KDM4EHTTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4746965-A1 | BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025017041-A1 | BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-23 | — | — | WO | disclosed |