Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2450616 | 0.83 | BRD4 (0.35) | IMPDH2 | |
| SCHEMBL2451710 | 0.83 | BRD4 (0.35) | IMPDH2 | |
| SCHEMBL2449466 | 0.83 | CREBBP (0.38) | IMPDH2PRKCQ | |
| SCHEMBL3136145 | 0.83 | LMNA (0.32) | — | |
| SCHEMBL2446023 | 0.80 | SYK (0.36) | IMPDH2EGFRITK | |
| SCHEMBL2446856 | 0.79 | BRD4 (0.36) | IMPDH2 | |
| SCHEMBL2448247 | 0.78 | BRD4 (0.37) | IMPDH2PRKCQ | |
| SCHEMBL2449771 | 0.76 | BRD4 (0.34) | IMPDH2 | |
| SCHEMBL2451572 | 0.75 | CREBBP (0.39) | IMPDH2 | |
| SCHEMBL2447398 | 0.75 | BRD4 (0.37) | IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |