Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136142 | 0.83 | IMPDH2 (0.32) | — | |
| SCHEMBL2450616 | 0.75 | BRD4 (0.35) | LMNAKMT2AKDM4EALDH1A1POLB | |
| SCHEMBL2451572 | 0.74 | CREBBP (0.39) | LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL2449466 | 0.74 | CREBBP (0.38) | — | |
| SCHEMBL2451712 | 0.74 | TNK2 (0.42) | LMNAALOX15MAPK1RECQLKMT2A | |
| SCHEMBL2448242 | 0.73 | TNK2 (0.43) | LMNAALOX15MAPK1RECQLKDM4E | |
| SCHEMBL2448252 | 0.73 | TNK2 (0.43) | LMNAALOX15MAPK1RECQLKDM4E | |
| SCHEMBL2446856 | 0.72 | BRD4 (0.36) | LMNAKMT2AKDM4EALDH1A1POLB | |
| SCHEMBL2447109 | 0.72 | TNK2 (0.46) | LMNAALOX15MAPK1RECQLTSHR | |
| SCHEMBL2450149 | 0.72 | CREBBP (0.43) | LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |