Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31364657 | 0.90 | AURKA (0.40) | AURKARPS6KB1EGFRGSK3BDYRK1A | |
| SCHEMBL31364650 | 0.79 | JAK2 (0.48) | JAK2JAK1EGFRDYRK1A | |
| SCHEMBL31364618 | 0.75 | JAK2 (0.47) | JAK2JAK1EGFRDYRK1A | |
| SCHEMBL31364649 | 0.74 | JAK2 (0.46) | AURKARPS6KB1JAK2JAK1EGFR | |
| SCHEMBL20520009 | 0.69 | GSK3B (0.47) | EGFRGSK3BDYRK1AATRSTK17B | |
| SCHEMBL21397386 | 0.69 | LCK (0.43) | GSK3BDYRK1AATRSTK17BSTK17A | |
| SCHEMBL29891274 | 0.69 | LCK (0.43) | GSK3BDYRK1AATRSTK17BSTK17A | |
| SCHEMBL18805591 | 0.68 | ATR (0.45) | EGFRGSK3BDYRK1AATRAURKB | |
| SCHEMBL29400652 | 0.68 | ATR (0.45) | EGFRGSK3BDYRK1AATRAURKB | |
| SCHEMBL20350467 | 0.68 | LCK (0.50) | GSK3BDYRK1AATRSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025020886-A1 | AZAQUINAZOLINE RING DERIVATIVE AND USE THEREOF | 浙江星浩澎博医药有限公司 | 2025-01-30 | — | — | WO | disclosed |