SCHEMBL31366876

SCHEMBL31366876

C#CCNC(=O)c1ccc(F)c(F)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
CA9 Q16790 1/20 0.54
CA14 Q9ULX7 1/20 0.54
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
S1PR3 Q99500 1/20 0.47
NAMPT P43490 1/20 0.46
KCNQ3 O43525 4/20 0.44
KCNQ2 O43526 4/20 0.44
TAS1R3 Q7RTX0 1/20 0.44
TAS1R1 Q7RTX1 1/20 0.44
TAS1R2 Q8TE23 1/20 0.44
HDAC1 Q13547 2/20 0.44
HDAC6 Q9UBN7 1/20 0.44
KCNQ5 Q9NR82 1/20 0.43
HDAC3 O15379 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22231515 1.00 CA12 (0.54) CA12CA1CA2CA9CA14
SCHEMBL22231457 0.87 CA12 (0.51) CA12CA1CA2CA9CA14
SCHEMBL26799630 0.87 HDAC1 (0.61) CA12CA1CA2CA9CA14
SCHEMBL22231390 0.86 MAOA (0.50) CA12CA1CA2CA9CA14
SCHEMBL18704364 0.86 CA12 (0.50) CA12CA1CA2CA9CA14
SCHEMBL2228826 0.85 CES2 (0.50) CES2CES1KCNQ3KCNQ2TAS1R3
SCHEMBL22231459 0.84 HDAC3 (0.46) CES2CES1MAOAMAOBKCNQ3
SCHEMBL921426 0.83 CA12 (0.48) CA12CA1CA2CA9CA14
SCHEMBL18704398 0.83 KIF11 (0.48) CA12CA1CA2CA9CA14
SCHEMBL30978666 0.83 KIF11 (0.48) CA12CA1CA2CA9CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119421874-A Aromatic amide derivative and application thereof in antitumor drugs 上海喆邺生物科技有限公司 2025-02-11 CN disclosed