Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CPB1 | P15086 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.32 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31367143 | 0.93 | HTT (0.36) | HTTMITFMAPTHTR2CCPB1 | |
| SCHEMBL31367163 | 0.89 | HTT (0.37) | HTTMITFMAPTHTR2CCPB1 | |
| SCHEMBL31367126 | 0.89 | CPB1 (0.38) | HTTMITFMAPTHTR2CCPB1 | |
| SCHEMBL31367142 | 0.88 | HTT (0.37) | HTTMITFMAPTHTR2CCPB1 | |
| SCHEMBL31367131 | 0.87 | HTT (0.36) | HTTMITFMAPTHTR2CCPB1 | |
| SCHEMBL31367144 | 0.86 | HTT (0.36) | HTTMITFMAPTHTR2CCPB1 | |
| SCHEMBL31367147 | 0.86 | HTT (0.36) | HTTMITFMAPTHTR2CCPB1 | |
| SCHEMBL21359903 | 0.85 | EPHX2 (0.30) | — | |
| SCHEMBL31367151 | 0.85 | HTR2C (0.43) | HTTMITFMAPTHTR2CCPB1 | |
| SCHEMBL31367157 | 0.84 | HTT (0.37) | HTTMITFMAPTHTR2CCPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12215116-B2 | Arginase inhibitors and methods of use | MERCK SHARP & DOHME LLC (US) | 2025-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12215116-B2 | Arginase inhibitors and methods of use | ARG1, ARG2, PRMT1 | HTT 4329/4885MITF 1998/4885MAPT 4192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.