Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3140214 | 0.82 | CHRM2 (0.40) | HDAC1HDAC6CHRM2CHRM1CHRM3 | |
| SCHEMBL3144371 | 0.80 | FAAH (0.53) | HDAC1HDAC6CHRM2CHRM1CHRM3 | |
| SCHEMBL3136720 | 0.76 | FAAH (0.68) | HDAC1HDAC6FAAH | |
| SCHEMBL6207882 | 0.76 | FAAH (0.49) | FAAH | |
| SCHEMBL21002124 | 0.75 | TAAR1 (0.69) | HDAC1HDAC6CHRM2CHRM1CHRM3 | |
| SCHEMBL21002162 | 0.73 | TAAR1 (0.71) | HDAC1HDAC6CHRM2CHRM1CHRM3 | |
| SCHEMBL12300796 | 0.72 | HDAC1 (0.54) | HDAC1HDAC6CHRM2CHRM1CHRM3 | |
| SCHEMBL11542204 | 0.71 | ABCB1 (0.58) | HDAC1HDAC6CHRM2CHRM1CHRM3 | |
| SCHEMBL1172674 | 0.71 | SLC2A1 (0.61) | HDAC1HDAC6CHRM2CHRM1CHRM3 | |
| SCHEMBL13129847 | 0.71 | FAAH (0.44) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268817-B2 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100075931-A1 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-03-25 | — | — | US | disclosed |
| EP-2068862-A2 | SUBSTITUTED OXAZOLE KETONE MODULATORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008030532-A2 | SUBSTITUTED OXAZOLE KETONE MODULATORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075931-A1 | Substituted oxazole ketone modulators of fatty acid amide hydrolase | FAAH, FAAH2, HCRTR2 | HDAC1 109/4885HDAC6 307/4885CHRM2 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.