Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 10/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13129847 | 0.92 | FAAH (0.44) | FAAHCES1NCEH1 | |
| SCHEMBL6668396 | 0.83 | CES1 (0.40) | FAAHCES1NCEH1 | |
| SCHEMBL24814189 | 0.83 | FAAH (0.45) | FAAHCES1NCEH1HPGD | |
| SCHEMBL7042177 | 0.78 | METAP2 (0.41) | FAAHCES1NCEH1 | |
| SCHEMBL5431177 | 0.78 | METAP2 (0.41) | FAAHCES1NCEH1 | |
| SCHEMBL5954984 | 0.78 | METAP2 (0.41) | FAAHCES1NCEH1 | |
| SCHEMBL12342279 | 0.78 | FAAH (0.49) | FAAHCES1NCEH1 | |
| SCHEMBL24814124 | 0.77 | FAAH (0.46) | FAAHCES1NCEH1 | |
| SCHEMBL13129849 | 0.76 | KMT2A (0.41) | FAAHCES1NCEH1 | |
| SCHEMBL6476667 | 0.76 | GRIN2D (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515726-A1 | MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004002491-A1 | MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-01-08 | — | — | WO | disclosed |