Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL2173873 | 0.98 | BLM (0.48) | — | |
| Proline SCHEMBL6894672 | 0.97 | BLM (0.52) | — | |
| Proline SCHEMBL462225 | 0.97 | BLM (0.52) | — | |
| Proline SCHEMBL18875607 | 0.97 | — | — | |
| Proline SCHEMBL10141185 | 0.97 | — | — | |
| Proline SCHEMBL10141181 | 0.97 | — | — | |
| Proline SCHEMBL718906 | 0.97 | BLM (0.52) | — | |
| Proline SCHEMBL13248912 | 0.97 | — | — | |
| D-Proline SCHEMBL21462052 | 0.97 | BLM (0.52) | — | |
| Proline SCHEMBL462226 | 0.97 | BLM (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119775261-A | Collagen 1 translation inhibitors and methods of use thereof | 艾尼莫生物科技公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-115427404-B | Collagen 1 translation inhibitors and methods of use thereof | 艾尼莫生物科技公司 | 2024-12-13 | — | — | CN | disclosed |