Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 4/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL31370901 | 0.98 | — | — | |
| Proline SCHEMBL6894672 | 0.95 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL462226 | 0.95 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL18875607 | 0.95 | — | — | |
| Proline SCHEMBL718906 | 0.95 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL10141181 | 0.95 | — | — | |
| Proline SCHEMBL10141185 | 0.95 | — | — | |
| Proline SCHEMBL13248912 | 0.95 | — | — | |
| D-Proline SCHEMBL21462052 | 0.95 | BLM (0.52) | BLMMEN1KMT2ANOS2NOS3 | |
| Proline SCHEMBL2939 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111410666-A | Process for preparing sulfonamide compound | 苏州亚盛药业有限公司 | 2020-07-14 | — | — | CN | claimed |
| US-11370807-B2 | Process for preparing sulfonamide compounds | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2022-06-28 | — | — | US | disclosed |
| US-20220009952-A1 | PROCESS FOR PREPARING SULFONAMIDE COMPOUNDS | ASCENTAGE PHARMA GROUP CORP LIMITED (CN) | 2022-01-13 | — | — | US | disclosed |
| EP-3820878-A1 | PROCESS FOR PREPARING SULFONAMIDE COMPOUNDS | Ascentage Pharma (Suzhou) Co., Ltd. (CN) | 2021-05-19 | — | — | EP | disclosed |
| CN-111410666-B | Process for preparing sulfonamide compound | 苏州亚盛药业有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-111410666-A | Process for preparing sulfonamide compound | 苏州亚盛药业有限公司 | 2020-07-14 | — | — | CN | disclosed |
| WO-2020140956-A1 | PROCESS FOR PREPARING SULFONAMIDE COMPOUNDS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2020-07-09 | — | — | WO | disclosed |
| US-9458155-B2 | Pyrido[4,3-b]indoles containing rigid moieties | MEDIVATION TECHNOLOGIES, INC (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150051218-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. | 2015-02-19 | — | — | US | disclosed |
| US-8907097-B2 | Pyrido[4,3-b]indoles containing rigid moieties | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906925-B2 | Pyrido[4,3-B]indoles containing rigid moieties | MEDIVATION TECHNOLOGIES, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20130190322-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| EP-2346332-A1 | PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES | Medivation Technologies, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| US-20100216814-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. | 2010-08-26 | — | — | US | disclosed |
| WO-2010051501-A1 | PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES | MEDIVATION TECHNOLOGIES, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051218-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | HTR3B, HTR3D, HTR3A | BLM 4700/4885MEN1 4283/4885KMT2A 366/4885 |
| US-11370807-B2 | Process for preparing sulfonamide compounds | BCL2, BCL3, BAX | BLM 4584/4885MEN1 4035/4885KMT2A 480/4885 |
| US-20130190322-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | HTR3B, HTR3D, HTR3A | BLM 4700/4885MEN1 4283/4885KMT2A 366/4885 |
| US-20100216814-A1 | PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES | HTR3B, HTR3D, HTR3A | BLM 4700/4885MEN1 4283/4885KMT2A 366/4885 |
| US-20220009952-A1 | PROCESS FOR PREPARING SULFONAMIDE COMPOUNDS | BCL2, BCL3, BAX | BLM 4584/4885MEN1 4035/4885KMT2A 480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.