SCHEMBL3137330

SCHEMBL3137330

COc1ccc(C2(c3ccc(N4CCOCC4)cc3)C=Cc3c4c(c5ccccc5c3O2)-c2ccccc2C4(C)C)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.36
PRKDC P78527 3/20 0.35
TP53 P04637 1/20 0.35
THRB P10828 1/20 0.35
PIK3CD O00329 1/20 0.35
PIK3CA P42336 1/20 0.35
PGR P06401 1/20 0.34
MAPT P10636 4/20 0.34
ALDH1A1 P00352 3/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
KDM4E B2RXH2 2/20 0.34
HTT P42858 2/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
LMNA P02545 1/20 0.34
AKR1C3 P42330 1/20 0.33
ATM Q13315 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
STK10 O94804 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29514499 1.00 RAB9A (0.36) RAB9APRKDCTP53THRBPIK3CD
SCHEMBL25606729 0.94 ATM (0.35) RAB9APRKDCTP53PGRMAPT
SCHEMBL25606848 0.94 RAB9A (0.34) RAB9APRKDCPGRMAPTALDH1A1
SCHEMBL25606847 0.94 RAB9A (0.34) RAB9APRKDCPGRMAPTALDH1A1
SCHEMBL25716067 0.94 PDK2 (0.34) RAB9APRKDCTHRBPIK3CDPIK3CA
SCHEMBL30914180 0.93 RAB9A (0.35) RAB9APRKDCTP53THRBPIK3CD
SCHEMBL1710974 0.93 RAB9A (0.35) RAB9APRKDCTP53THRBPIK3CD
SCHEMBL1333000 0.93 RAB9A (0.35) RAB9APRKDCTP53THRBPIK3CD
SCHEMBL25717701 0.93 ATM (0.36) RAB9APRKDCTP53MAPTALDH1A1
SCHEMBL14617523 0.93 PGR (0.34) RAB9APGRMAPTALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4269532-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-11-01 EP disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed
EP-4198583-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed
US-9588257-B2 Photochromic curable composition TOKUYAMA CORPORATION (JP) 2017-03-07 US disclosed
US-9588257-B2 Photochromic curable composition TOKUYAMA CORPORATION (JP) 2017-03-07 US disclosed
EP-2769998-B1 (METH)ACRYLATE COMPOUND, AND PHOTOCHROMIC CURABLE COMPOSITION CONTAINING SAID (METH)ACRYLATE COMPOUND TOKUYAMA CORP (JP) 2016-08-03 EP disclosed
US-20160116765-A1 PHOTOCHROMIC CURABLE COMPOSITION TOKUYAMA CORPORATION (JP) 2016-04-28 US disclosed
WO-2013058218-A1 (METH)ACRYLATE COMPOUND, AND PHOTOCHROMIC CURABLE COMPOSITION CONTAINING SAID (METH)ACRYLATE COMPOUND 株式会社トクヤマ (JP) 2013-04-25 WO disclosed
US-8308995-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2012-11-13 US disclosed
US-8308995-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2012-11-13 US disclosed
US-20120138876-A1 CHROMENE COMPOUND KASAI SOKO (JP) 2012-06-07 US disclosed
US-20120138876-A1 CHROMENE COMPOUND KASAI SOKO (JP) 2012-06-07 US disclosed
US-8147726-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2012-04-03 US disclosed
US-8147726-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2012-04-03 US disclosed
US-20110062396-A1 CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2011-03-17 US disclosed
US-20110062396-A1 CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2011-03-17 US disclosed
EP-1963896-B1 PHOTOCHROMIC MATERIALS HAVING ELECTRON-WITHDRAWING SUBSTITUENTS TRANSITIONS OPTICAL INC (US) 2010-02-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120138876-A1 CHROMENE COMPOUND CHRM1, CBX8, CBX7 RAB9A 1112/4885PRKDC 4749/4885TP53 457/4885
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES NR2E3, CRY1, RPS10 RAB9A 1795/4885PRKDC 4850/4885TP53 4259/4885
US-20110062396-A1 CHROMENE COMPOUND CDYL, NR0B1, NR1H2 RAB9A 841/4885PRKDC 4283/4885TP53 3872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.