Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Difenoximide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 9/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.68 |
| ▸ | CCR1 | P32246 | 8/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Difenoximide SCHEMBL1818240 | 0.98 | KCNA3 (0.73) | KCNA3OPRM1CCR1RAB9ANPSR1 | |
| Difenoximide SCHEMBL121671 | 0.97 | KCNA3 (0.72) | KCNA3OPRM1CCR1RAB9ANPSR1 | |
| SCHEMBL11604250 | 0.85 | KCNA3 (0.84) | KCNA3OPRM1CCR1RAB9ANPSR1 | |
| Difenoxin SCHEMBL123801 | 0.81 | KCNA3 (0.78) | KCNA3OPRM1CCR1RAB9ANPSR1 | |
| Diphenoxylate SCHEMBL42940 | 0.81 | OPRM1 (1.00) | KCNA3OPRM1 | |
| Difenoxin SCHEMBL149008 | 0.81 | KCNA3 (0.76) | KCNA3OPRM1CCR1RAB9ANPSR1 | |
| Difenoxin SCHEMBL11604884 | 0.81 | KCNA3 (0.76) | KCNA3OPRM1CCR1RAB9ANPSR1 | |
| Diphenoxylate SCHEMBL42124 | 0.81 | OPRM1 (0.98) | KCNA3OPRM1 | |
| Diphenoxylate SCHEMBL20595320 | 0.81 | OPRM1 (0.98) | KCNA3OPRM1 | |
| Diphenoxylate SCHEMBL28385054 | 0.81 | OPRM1 (0.98) | KCNA3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2151846-B1 | High temperature thermal cutoff device | THERM O DISC INC (US) | 2013-10-09 | — | — | EP | disclosed |
| CN-101685733-A | High-temperature thermal fuse device | THERM O DISC INC | 2010-03-31 | — | — | CN | disclosed |
| EP-2151846-A2 | High temperature thermal cutoff device | Therm-O-Disc Incorporated (US) | 2010-02-10 | — | — | EP | disclosed |