SCHEMBL31379014

SCHEMBL31379014

O=c1oc2cc(Cc3ccccc3)ccc2cc1C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR55 Q9Y2T6 3/20 0.49
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA3 P07451 1/20 0.44
CA4 P22748 1/20 0.44
CA5A P35218 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
CA5B Q9Y2D0 1/20 0.44
AR P10275 2/20 0.43
ESR1 P03372 1/20 0.43
HSD17B3 P37058 1/20 0.43
POLB P06746 1/20 0.43
S1PR1 P21453 1/20 0.40
S1PR3 Q99500 1/20 0.40
NPC1 O15118 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
VKORC1 Q9BQB6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27935835 0.81 MEN1 (0.44) GPR55CA12CA2CA3CA4
SCHEMBL104995 0.79 AR (0.67) CA12CA1CA2CA3CA4
SCHEMBL27922315 0.78 POLB (0.58) GPR55CA12CA1CA2CA3
SCHEMBL10884420 0.78 POLB (0.58) GPR55CA12CA1CA2CA3
Benzyl Alcohol SCHEMBL333772 0.78 MAOB (0.48) CA12CA1CA2CA3CA4
SCHEMBL7544470 0.77 HPGD (0.55) CA12CA1CA2CA3CA4
SCHEMBL383681 0.77 HPGD (0.55) CA12CA1CA2CA3CA4
Ammonia Solution, Strong SCHEMBL6994460 0.76 HPGD (0.53) CA12CA1CA2CA3CA4
Dimethylamine SCHEMBL5140932 0.75 HPGD (0.49) CA12CA1CA2CA3CA4
SCHEMBL15842332 0.74 PGR (0.43) ARHSD17B3MAOBMAOAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112313238-B Tetrahydropyranoxazine derivatives with selective BACE1 inhibiting activity 盐野义制药株式会社 2025-01-17 CN disclosed