Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | CCR1 | P32246 | 3/20 | 0.63 |
| ▸ | CCR5 | P51681 | 3/20 | 0.63 |
| ▸ | CCR8 | P51685 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | ALPL | P05186 | 1/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.63 |
| ▸ | ALPI | P09923 | 1/20 | 0.63 |
| ▸ | ALPG | P10696 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | METAP1 | P53582 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3167663 | 0.85 | CCR1 (0.48) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL14732968 | 0.85 | KDM4E (0.63) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL9146011 | 0.83 | CCR1 (0.46) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL14095574 | 0.83 | KDM4E (0.61) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL18769070 | 0.82 | KDM4E (0.65) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL13596181 | 0.81 | KDM4E (0.63) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL20863011 | 0.81 | KDM4E (0.63) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL2720567 | 0.81 | KDM4E (0.63) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL2085837 | 0.81 | KDM4E (0.63) | KDM4ESMN1; SMN2LMNACCR1CCR5 | |
| SCHEMBL15217633 | 0.81 | KDM4E (0.63) | KDM4ESMN1; SMN2LMNACCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11067580-B2 | Compounds and methods for conjugation of biomolecules | Life Technologies Corporation (US) | 2021-07-20 | — | — | US | disclosed |
| US-11067580-B2 | Compounds and methods for conjugation of biomolecules | Life Technologies Corporation (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200333351-A1 | Compounds and Methods for Conjugation of Biomolecules | Life Technologies Corporation | 2020-10-22 | — | — | US | disclosed |
| US-20200333351-A1 | Compounds and Methods for Conjugation of Biomolecules | Life Technologies Corporation | 2020-10-22 | — | — | US | disclosed |
| US-10648985-B2 | Compounds and methods for conjugation of biomolecules | Life Technologies Corporation (US) | 2020-05-12 | — | — | US | disclosed |
| US-10648985-B2 | Compounds and methods for conjugation of biomolecules | Life Technologies Corporation (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190079095-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | Life Technologies Corporation | 2019-03-14 | — | — | US | disclosed |
| US-20190079095-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | Life Technologies Corporation | 2019-03-14 | — | — | US | disclosed |
| EP-2966061-B1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | LIFE TECHNOLOGIES CORP (US) | 2017-05-03 | — | — | EP | disclosed |
| EP-2966061-B1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | LIFE TECHNOLOGIES CORP (US) | 2017-05-03 | — | — | EP | disclosed |
| US-8093395-B2 | Sphingosine compound, method for producing the same, and sphingomyelinase inhibitor | OTSUKA CHEMICAL CO., LTD. (JP) | 2012-01-10 | — | — | US | disclosed |
| US-8093395-B2 | Sphingosine compound, method for producing the same, and sphingomyelinase inhibitor | OTSUKA CHEMICAL CO., LTD. (JP) | 2012-01-10 | — | — | US | disclosed |
| EP-2133335-B1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO LTD (JP) | 2011-09-28 | — | — | EP | disclosed |
| EP-2133335-B1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO LTD (JP) | 2011-09-28 | — | — | EP | disclosed |
| US-20100099881-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO., LTD. (JP) | 2010-04-22 | — | — | US | disclosed |
| US-20100099881-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO., LTD. (JP) | 2010-04-22 | — | — | US | disclosed |
| US-20100099881-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | OTSUKA CHEMICAL CO., LTD. (JP) | 2010-04-22 | — | — | US | disclosed |
| EP-2133335-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | Otsuka Chemical Co., Ltd. (JP) | 2009-12-16 | — | — | EP | disclosed |
| EP-2133335-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | Otsuka Chemical Co., Ltd. (JP) | 2009-12-16 | — | — | EP | disclosed |
| US-4598073-A | Certain polycyclo-palladium-bipyridine complexes having anti-tumor activity | RESEARCH CORPORATION (US) | 1986-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099881-A1 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR | SGPL1, SMPD1, SPHK1 | KDM4E 2512/4885SMN1; SMN2 1398/4885LMNA 1776/4885 |
| US-20190079095-A1 | COMPOUNDS AND METHODS FOR CONJUGATION OF BIOMOLECULES | LIG3, LIG1, HLCS | KDM4E 2864/4885SMN1; SMN2 3351/4885LMNA 3493/4885 |
| US-20200333351-A1 | Compounds and Methods for Conjugation of Biomolecules | LIG3, LIG1, HLCS | KDM4E 2864/4885SMN1; SMN2 3351/4885LMNA 3493/4885 |
| US-11067580-B2 | Compounds and methods for conjugation of biomolecules | LIG3, LIG1, HLCS | KDM4E 2864/4885SMN1; SMN2 3351/4885LMNA 3493/4885 |
| US-10648985-B2 | Compounds and methods for conjugation of biomolecules | LIG3, LIG1, HLCS | KDM4E 2864/4885SMN1; SMN2 3351/4885LMNA 3493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.