Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17979495 | 0.81 | CACNA1H (0.43) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL26656293 | 0.79 | L3MBTL1 (0.43) | CACNA1HCACNA1BCACNA1CLMNAKDM4A | |
| SCHEMBL28115513 | 0.78 | CACNA1H (0.51) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL13952493 | 0.77 | CA1 (0.43) | CACNA1HCACNA1BCACNA1CLMNAKDM4A | |
| SCHEMBL15385130 | 0.76 | CACNA1H (0.46) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL26657670 | 0.76 | STK17B (0.47) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL30670723 | 0.76 | STK17B (0.47) | CACNA1HCACNA1BCACNA1CLMNAPOLB | |
| SCHEMBL19971719 | 0.74 | L3MBTL1 (0.44) | CACNA1HCACNA1BCACNA1CLMNAKDM4A | |
| SCHEMBL19794866 | 0.74 | TRPA1 (0.49) | CACNA1HCACNA1BCACNA1CCA12CA1 | |
| SCHEMBL3633138 | 0.74 | KDM4A (0.54) | KDM4ACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068985-A1 | 1-(1-OXO-1,2-DIHYDROPHTHALAZIN-6-YL)CYCLOALKYL-1-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 | BEIGENE SWITZERLAND GMBH (CH) | 2025-04-03 | — | — | WO | disclosed |
| CN-119707931-A | Intermediate and synthesis method of 1- (1-oxo-1, 2-dihydro-phthalazin-6-yl) cycloalkyl-1-carboxamide derivatives as MTA synergistic inhibitors of PRMT5 | 百济神州(北京)生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |