Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4500319 | 0.99 | HPGD (0.39) | RAB9AHPGDMEN1KMT2ACYP2D6 | |
| SCHEMBL13523570 | 0.87 | TRPV3 (0.36) | RAB9AHPGDMEN1KMT2ACYP2D6 | |
| SCHEMBL3128705 | 0.86 | GNE (0.40) | RAB9AHPGDMEN1KMT2ACYP2D6 | |
| SCHEMBL13600522 | 0.86 | TRPV3 (0.37) | RAB9AHPGDMEN1KMT2ACYP2D6 | |
| SCHEMBL3136957 | 0.85 | HPGD (0.40) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL4489665 | 0.85 | HPGD (0.41) | RAB9AHPGDMEN1KMT2ACYP2D6 | |
| SCHEMBL4487940 | 0.84 | HPGD (0.41) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL4484410 | 0.81 | KDM5A (0.34) | SMN1; SMN2TSHRLMNAMAPTHTT | |
| SCHEMBL4484417 | 0.81 | KDM5A (0.34) | SMN1; SMN2TSHRLMNAMAPTHTT | |
| SCHEMBL13762558 | 0.81 | RAB9A (0.44) | RAB9AHPGDMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
| WO-2010011864-A2 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | WO | disclosed |
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | H1-4, H1-5, H1-3 | RAB9A 4442/4885HPGD 1495/4885MEN1 1696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.