Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNE | Q9Y223 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 11/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 10/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489665 | 0.99 | HPGD (0.41) | GNERAB9AHPGDMEN1KMT2A | |
| SCHEMBL3136957 | 0.86 | HPGD (0.40) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL3138155 | 0.86 | RAB9A (0.38) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL4500319 | 0.85 | HPGD (0.39) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL4487940 | 0.85 | HPGD (0.41) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL13762558 | 0.84 | RAB9A (0.44) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL3392295 | 0.83 | ALDH1A1 (0.36) | LMNATSHRALDH1A1 | |
| SCHEMBL13523569 | 0.82 | HPGD (0.37) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL13600517 | 0.81 | HPGD (0.39) | RAB9AHPGDMEN1KMT2ANPC1 | |
| SCHEMBL13523736 | 0.81 | RAB9A (0.39) | GNERAB9AHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | H1-4, H1-5, H1-3 | GNE 2755/4885RAB9A 4442/4885HPGD 1495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.